Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,820.00 | |
50 mg | 8-10 weeks | $ 2,380.00 | |
100 mg | 8-10 weeks | $ 3,100.00 |
Description | AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM). |
Targets&IC50 | MDM2:25 nM |
In vitro | AM-8735 exhibits a dose-dependent increase of p21 mRNA, a direct transcriptional readout of p53 activity, in HCT116 p53wt cells (IC50=160 nM)[1]. AM-8735 displays substantial growth inhibition of wild-type p53 cells (IC50=63 nM) and no growth inhibition of p53-deficient cells (IC50>25 μM). |
In vivo | AM-8735 exhibits potent antitumor properties in the SJSA-1 osteosarcoma xenograft model, achieving an effective dose (ED50) of 41 mg/kg[1]. Additionally, AM-8735 significantly induces p21 mRNA expression in a time- and concentration-dependent manner within SJSA-1 osteosarcoma tumors, as demonstrated through in vivo pharmacodynamic assays. |
Molecular Weight | 568.51 |
Formula | C27H31Cl2NO6S |
CAS No. | 1429386-01-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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AM-8735 1429386-01-5 Apoptosis Mdm2 AM8735 AM 8735 inhibitor inhibit