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Urease Inhibitor 07

Name: Urease Inhibitor 07
Brand: TargetMol
SKU: T67827
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67827Cas No. 15264-63-8

Urease Inhibitor 07 is an isosubstituted metalloproteinase inhibitor with potential activity against Mycobacterium tuberculosis strain H37Rv.

Urease Inhibitor 07

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Purity: 99.65%

Catalog No. T67827Cas No. 15264-63-8

Urease Inhibitor 07 is an isosubstituted metalloproteinase inhibitor with potential activity against Mycobacterium tuberculosis strain H37Rv.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.65%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Urease Inhibitor 07 AI Summary

Urease Inhibitor 07 exhibits a broad spectrum of bioactivity, including significant antimicrobial, anti-inflammatory, analgesic, and enzymatic inhibition effects. It demonstrates antimicrobial activity against Staphylococcus aureus, Candida tropicalis, and Candida albicans, with inhibition zones of 10.0 mm, 30.0 mm, and 25.0 mm respectively, based on well diffusion method assays. Additionally, it shows antiamebic activity against Entamoeba histolytica HM-1:IMSS with an IC50 of 558.0 nM and displays cytotoxicity against human MCF7 cells with an IC50 greater than 250,000.0 nM. Urease Inhibitor 07 also inhibits snake venom NPP1 (IC50 > 1000000.0 nM), mushroom tyrosinase (Ki = 14200.0 nM), and Populus sieboldii x Populus grandidentata trans-cinnamate 4-hydroxylase expressed in Saccharomyces cerevisiae (IC50 = 15000.0 nM). The compound exhibits anti-inflammatory and analgesic activities with inhibition rates of 62.88% and 54.28% respectively, but also shows gastrointestinal toxicity, indicated by an ulcerogenic index of 1.327 and elevated malonaldehyde levels at 5.78 nmol per 100 mg of tissue..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Urease Inhibitor 07 is an isosubstituted metalloproteinase inhibitor with potential activity against Mycobacterium tuberculosis strain H37Rv.

Chemical Properties

Molecular Weight	179.2
Formula	C₇H₅N₃OS
Cas No.	15264-63-8
Smiles	S=C1NN=C(O1)C1=CC=NC=C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (139.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5804 mL	27.9018 mL	55.8036 mL	279.0179 mL
5 mM	1.1161 mL	5.5804 mL	11.1607 mL	55.8036 mL
10 mM	0.5580 mL	2.7902 mL	5.5804 mL	27.9018 mL
20 mM	0.2790 mL	1.3951 mL	2.7902 mL	13.9509 mL
50 mM	0.1116 mL	0.5580 mL	1.1161 mL	5.5804 mL
100 mM	0.0558 mL	0.2790 mL	0.5580 mL	2.7902 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc