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4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid
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Catalog No. TN7172Cas No. 34649-21-3
Alias 4,5-dibromopyrrole-2-carboxylic acid, 4,5-Dibromo-2-pyrrolic acid
4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid (4,5-Dibromo-2-pyrrolic acid) is a marine derived natural products found in Agelas oroides.
4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid
Copy Product Info🥰Excellent
Purity: 96.06%
Catalog No. TN7172Alias 4,5-dibromopyrrole-2-carboxylic acid, 4,5-Dibromo-2-pyrrolic acidCas No. 34649-21-3
4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid (4,5-Dibromo-2-pyrrolic acid) is a marine derived natural products found in Agelas oroides.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $35 | In Stock | In Stock | |
| 10 mg | $54 | In Stock | In Stock | |
| 25 mg | $96 | In Stock | In Stock | |
| 50 mg | $153 | In Stock | - |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:96.06%
Appearance:Solid
Color:Black
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Product Introduction
4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid AI Summary
4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid exhibits a range of bioactivities, including inhibition of Plasmodium falciparum FabI with an IC50 greater than 100.0 µg/mL and antimalarial activity against chloroquine-resistant and pyrimethamine-resistant Plasmodium falciparum K1 with an IC50 greater than 50.0 µg/mL after 48 hours. It also shows antitrypanosomal activity against Trypanosoma brucei rhodesiense with an IC50 of 20.9 µg/mL after 72 hours and limited activity against Trypanosoma cruzi with an IC50 greater than 30.0 µg/mL after 72 hours. Additionally, 4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid has antileishmanial activity against Leishmania donovani with an IC50 of 7.9 µg/mL after 72 hours and cytotoxicity against rat L6 cells with an IC50 greater than 90.0 µg/mL after 72 hours.
Moreover, 4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid demonstrates strong immunosuppressive activity against mouse splenocytes by inhibiting [3H]thymidine incorporation up to 100% at concentrations of up to 15.6 µg/mL, with the activity decreasing gradually at higher concentrations. It also exhibits cytotoxicity against mouse splenocytes, as determined by the MTT assay, showing high levels of cell viability inhibition, notably exceeding 100% at lower concentrations, such as 0.5 µg/mL..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid (4,5-Dibromo-2-pyrrolic acid) is a marine derived natural products found in Agelas oroides. |
| Synonyms | 4,5-dibromopyrrole-2-carboxylic acid, 4,5-Dibromo-2-pyrrolic acid |
| Molecular Weight | 268.89 |
| Formula | C5H3Br2NO2 |
| Cas No. | 34649-21-3 |
| Smiles | OC(=O)C1=CC(Br)=C(Br)N1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 2.69 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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