Powder: -20°C for 3 years | In solvent: -80°C for 1 year
N-Desethyl Bimatoprost (17-phenyl trinor PGF2α amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs. Although it has been claimed that PG amides are not converted to the free acids in vivo, studies have shown that bovine and human corneal tissue converts the amides of various PGs to the free acids with a conversion efficiency of about 10-20% relative to the hydrolysis of isopropyl esters. 17-phenyl trinor PGF2α amide would be expected to show the typical intraocular effects of latanoprost, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 160.00 | |
5 mg | 35 days | $ 686.00 | |
10 mg | 35 days | $ 1,240.00 |
Description | N-Desethyl Bimatoprost (17-phenyl trinor PGF2α amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs. Although it has been claimed that PG amides are not converted to the free acids in vivo, studies have shown that bovine and human corneal tissue converts the amides of various PGs to the free acids with a conversion efficiency of about 10-20% relative to the hydrolysis of isopropyl esters. 17-phenyl trinor PGF2α amide would be expected to show the typical intraocular effects of latanoprost, but with the much slower hydrolysis pharmacokinetics of the PG N-amides. |
Synonyms | 17-phenyl trinor Prostaglandin F2α amide |
Molecular Weight | 387.51 |
Formula | C23H33NO4 |
CAS No. | 155205-89-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL
DMF: 30 mg/mL
Ethanol: 20 mg/mL
PBS (pH 7.2): 2 mg/mL
You can also refer to dose conversion for different animals. More
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N-Desethyl Bimatoprost 155205-89-3 17-phenyl trinor Prostaglandin F2a Amide 17-phenyl trinor Prostaglandin F-2α amide 17phenyl trinor Prostaglandin F2α amide 17-phenyl trinor Prostaglandin F2α amide 17-phenyl trinor Prostaglandin F2α Amide 17-phenyl trinor Prostaglandin F2alpha Amide 17 phenyl trinor Prostaglandin F2α amide inhibitor inhibit