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10-Hydroxypheophorbide A

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Catalog No. TN13693 Copy Product Info
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10-Hydroxypheophorbide A is a chlorophyll-related compound found in the leaves of Neptunia oleracea. It inhibits Epstein-Barr virus (EBV) activation mediated by tumor inducers and exhibits photoinduced cytotoxicity against cancer cells.

10-Hydroxypheophorbide A

Cas No. 83688-53-3
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
10-Hydroxypheophorbide A is a chlorophyll-related compound found in the leaves of Neptunia oleracea. It inhibits Epstein-Barr virus (EBV) activation mediated by tumor inducers and exhibits photoinduced cytotoxicity against cancer cells.
In vitro
10-Hydroxypheophorbide A (Compound 6) effectively inhibits the activation of EBV in Raji cells that is induced by teleocidin B-4, with an IC 50 of 18 μM. Within the concentration range of 0.05 to 50 μM, its inhibitory activity increases with concentration. The compound exhibits photocytotoxicity against Raji cells, showing non-irradiated pLC 50 at 4.92 and irradiated pLC 50 at 7.06, indicating that light exposure enhances its cytotoxic effect. Additionally, at a concentration of 50 μM, 10-Hydroxypheophorbide A accelerates the photoprotected peroxidation of ethyl linoleate in cell-free systems, reaching an OD 532 value of 0.426 after 30 hours of irradiation. In contrast, its inhibitory effect on EBV activation in Raji cells at 0.5 μM is not significantly enhanced by light, with inhibition rates of 0 ± 3% in the dark and 2 ± 8% under illumination.
Chemical Properties
Molecular Weight608.68
FormulaC35H36N4O6
Cas No.83688-53-3
SmilesC(OC)(=O)[C@]1(O)C=2C3=C(C1=O)C(C)=C(N3)C=C4C(CC)=C(C)C(=N4)C=C5NC(=CC6=NC2[C@@H](CCC(O)=O)[C@@H]6C)C(C)=C5C=C
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 µL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Related Tags: 10-Hydroxypheophorbide A in vitro | 10-Hydroxypheophorbide A formula | 10-Hydroxypheophorbide A molecular weight
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