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β-CGRP, human acetate

Catalog No. TP2167 CAS TP2167

Synonyms: CGRP-II (Human) (acetate), β-CGRP, human acetate (101462-82-2 free), Human β-CGRP acetate

β-CGRP, human acetate is one of calcitonin peptides and acts via the complex of receptor-activity-modifying protein (RAMP) and calcitonin-receptor-like receptor (CRLR) (IC50s: 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells).

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β-CGRP, human acetate, CAS TP2167

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	β-CGRP, human acetate is one of calcitonin peptides and acts via the complex of receptor-activity-modifying protein (RAMP) and calcitonin-receptor-like receptor (CRLR) (IC50s: 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells).
Targets&IC50	CRLR/RAMP1, cell assay:1 nM , CRLR/RAMP2, cell assay:300 nM
In vitro	β-CGRP, human acts via a complex of the CRLR and RAMP, with IC50s of 1 nM in both SK-N-MC and Swiss 3T3 cells express CRLR and RAMP1, and 300 nM and 130 nM in HEK293T and NG108-15 cells expressing CRLR and RAMP2 [1]. CGRP is a potent vasodilator and also exhibits pro- and -anti-inflammatory activity [2].

Synonyms	CGRP-II (Human) (acetate), β-CGRP, human acetate (101462-82-2 free), Human β-CGRP acetate
Molecular Weight	3853.46
Formula	C164H271N51O50S3
CAS No.	TP2167

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. McLatchie LM, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998 May 28;393(6683):333-9. 2. Russell FA, et al. Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 2014 Oct;94(4):1099-142.

Related Products

Related compounds with same targets

β-CGRP, human acetate Adrenomedullin (AM) (22-52), human acetate HCGRP-(8-37) acetate Calcitonin（salmon） Acetate(47931-85-1(free base)) Calcitonin (salmon) Vazegepant hydrochloride MK-3207 Hydrochloride Rimegepant

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Keywords

β-CGRP, human acetate TP2167 离子通道 CGRP Receptor Human β-CGRP acetate βCGRP, human acetate β CGRP, human acetate CGRP-II (Human) (acetate) β-CGRP, human acetate (101462-82-2 free) Inhibitor inhibitor inhibit

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