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(2R)-Octyl-α-hydroxyglutarate

Catalog No. T19611   CAS 1391194-67-4
Synonyms: (2R)-Octyl-2-HG

(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
(2R)-Octyl-α-hydroxyglutarate, CAS 1391194-67-4
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25 mg Inquiry $ 1,204.00
200 mg Inquiry $ 4,881.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description (2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form.
In vitro Treatment of IDH1-WT HeLa cells with (2R)-octyl-α-hydroxyglutaric acid (a modified form of 2-hydroxyglutaric acid with high cellular uptake) results in a dose-dependent DSB in log phase cells increase. It has been used to examine the contribution of D-2-hydroxyglutarate to the oxidative mitochondrial process of IDH1 mutant cancer cells.
Synonyms (2R)-Octyl-2-HG
Molecular Weight 260.33
Formula C13H24O5
CAS No. 1391194-67-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (384.13 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Sulkowski PL, et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologousrecombination and induces PARP inhibitor sensitivity. Sci Transl Med. 2017 Feb 1;9(375).

Related Products

Related compounds with same targets
Hispidulin CX-6258 hydrochloride Pim1/AKK1-IN-1 SMI-16a K00135 (2R)-Octyl-α-hydroxyglutarate CX-6258 M-110

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Keywords

(2R)-Octyl-α-hydroxyglutarate 1391194-67-4 Chromatin/Epigenetic JAK/STAT signaling Pim (2R)Octylαhydroxyglutarate (2R)-Octyl-2-HG (2R) Octyl α hydroxyglutarate Inhibitor inhibitor inhibit

 

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