Sucrose dilaurate

Sucrose dilaurate is an emulsifier, dispersant, and stabilizer. It reduces keratinocyte release of HMGB1 upon UVB exposure and inhibits melanin production while decreasing bilirubin levels. Additionally, sucrose dilaurate induces autophagy (autophagy) in human epidermal keratinocytes, lowering carboxymethyllysine (CML) levels. It also diminishes the secretion of insulin-like growth factor-binding protein 3 (IGFBP3) and nerve growth factor (NGF) by aging keratinocytes. In the cosmetic, food, and pharmaceutical industries, sucrose dilaurate is studied as an emulsifier, dispersant, or stabilizer.

Sucrose dilaurate, as a component of the SDL mixture comprising roughly a 6:4 ratio of sucrose dilaurate and sucrose dilaurate laureate, significantly reduces bilirubin levels when incubated in a cell-free system. It inhibits bilirubin production in hydrogen peroxide-induced human tKC keratinocytes, lowers bilirubin levels in HaCaT keratinocytes, and reduces bilirubin bound to human skin slices. Sucrose dilaurate at a concentration of 0.005% for 24 hours can notably induce autophagosome formation in neonatal human epidermal keratinocytes. Additionally, the compound at 0.01% for 24 hours significantly decreases CML levels in glyceraldehyde-treated neonatal human epidermal keratinocytes. Furthermore, at 0.001% over 72 hours, it markedly inhibits the release of IGFBP3 and NGF in doxorubicin-induced senescent HaCaT keratinocytes.