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alphaSYN-IN-NAB2

Catalog No. T23709 CAS 1504588-00-4

Synonyms: alphaSYN inhibitor NAB2, alphaSYNINNAB2, alphaSYN-IN-NAB2, NAB2, alphaSYN inhibitor-NAB2

alphaSYN-IN-NAB2, a neuron-protective agent, is a protein encoded by the NAB2 gene. NAB2 effectively and selectively protects a variety of cells from alpha-SYN toxicity. NAB2 promotes endosomal transport dependent on E3 ubiquitin ligase Rsp5/Nedd4. NAB2 identifies a viable molecular node in alpha-SYN biology that corrects multiple aspects of its underlying pathology, including dysfunctional endosomes and endoplasmic reticulum to Golgi vesicles transport. NAB2 is involved in cellular processes such as cell differentiation, apoptosis and stress response, and can be used to study cancer, neurodevelopment and neuronal activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

alphaSYN-IN-NAB2, CAS 1504588-00-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 94.00
5 mg	In stock	$ 225.00
10 mg	In stock	$ 338.00
25 mg	In stock	$ 541.00
50 mg	In stock	$ 778.00
100 mg	In stock	$ 1,090.00
500 mg	In stock	$ 2,180.00

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Purity: 99.56%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	alphaSYN inhibitor NAB2, alphaSYNINNAB2, alphaSYN-IN-NAB2, NAB2, alphaSYN inhibitor-NAB2
Molecular Weight	389.88
Formula	C23H20ClN3O
CAS No.	1504588-00-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 35.1 mg/mL (90.0 Mm)

Ethanol: 35.1 mg/mL (90.0 mM)

References and Literature

1. Wang L, et al. Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of α-synuclein and neuroinflammation. Cell Death Dis. 2018;9(5):440. 2. Shvadchak VV, et al. Inhibition of α-Synuclein Amyloid Fibril Elongation by Blocking Fibril Ends. Angew Chem Int Ed Engl. 2018;57(20):5690-5694. 3. Sturm E, Fellner L, Krismer F, Poewe W, Wenning GK, Stefanova N. Neuroprotection by Epigenetic Modulation in a Transgenic Model of Multiple System Atrophy. Neurotherapeutics. 2016 Oct;13(4):871-879. doi: 10.1007/s13311-016-0447-1. PubMed PMID: 27259295; PubMed Central PMCID: PMC5081120. 4. Delenclos M, Trendafilova T, Jones DR, Moussaud S, Baine AM, Yue M, Hirst WD, McLean PJ. A Rapid, Semi-Quantitative Assay to Screen for Modulators of Alpha-Synuclein Oligomerization Ex vivo. Front Neurosci. 2016 Jan 19;9:511. doi: 10.3389/fnins.2015.00511. eCollection 2015. PubMed PMID: 26834539; PubMed Central PMCID: PMC4717311.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

alphaSYN-IN-NAB2 1504588-00-4 NAB 2 alphaSYN inhibitor NAB2 alphaSYNINNAB2 NAB2 alphaSYN inhibitor-NAB2 NAB-2 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.