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ZD-8731 HCl

Catalog No. T29212 CAS 135015-84-8

Synonyms: ZD 8731, ZD-8731, ZD-8731 hydrochloride, ZD8731, ICI-D 8731, ICI-D-8731

ZD-8731, an angiotensin type 1 receptor antagonist, is used potentially for the treatment of hypertension and heart failure.

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ZD-8731 HCl, CAS 135015-84-8

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,820.00
50 mg	8-10 weeks	$ 2,380.00
100 mg	8-10 weeks	$ 3,100.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

ZD-8731, an angiotensin type 1 receptor antagonist, is used potentially for the treatment of hypertension and heart failure.

Synonyms	ZD 8731, ZD-8731, ZD-8731 hydrochloride, ZD8731, ICI-D 8731, ICI-D-8731
Molecular Weight	443.93
Formula	C25H22ClN5O
CAS No.	135015-84-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Geiger H, Fierlbeck W, Mai M, Ruchti H, Schönfeld V, Dämmrich J, Hugo C, Neumayer HH. Effects of early and late antihypertensive treatment on extracellular matrix proteins and mononuclear cells in uninephrectomized SHR. Kidney Int. 1997 Mar;51(3):750-61. PubMed PMID: 9067907. 2. Hoenack C, Roesen P. Inhibition of angiotensin type 1 receptor prevents decline of glucose transporter (GLUT4) in diabetic rat heart. Diabetes. 1996 Jan;45 Suppl 1:S82-7. PubMed PMID: 8529806. 3. Brilla CG, Zhou G, Rupp H, Maisch B, Weber KT. Role of angiotensin II and prostaglandin E2 in regulating cardiac fibroblast collagen turnover. Am J Cardiol. 1995 Nov 2;76(13):8D-13D. Review. PubMed PMID: 7495221. 4. Shaw LM, George PR, Oldham AA, Heagerty AM. A comparison of the effect of angiotensin converting enzyme inhibition and angiotensin II receptor antagonism on the structural changes associated with hypertension in rat small arteries. J Hypertens. 1995 Oct;13(10):1135-43. PubMed PMID: 8586805.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ZD-8731 HCl 135015-84-8 ZD 8731 ZD 8731 HCl ICI-D8731 ZD 8731 Hydrochloride ZD8731 Hydrochloride ZD-8731 ZD-8731 hydrochloride ZD8731 ICI-D 8731 ZD8731 HCl ICI-D-8731 ZD-8731 Hydrochloride inhibitor inhibit

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