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Targocil

Catalog No. T4208   CAS 1200443-21-5

Targocil is used as a bacteriostatic inhibitor of wall teichoic acid (WTA) biosynthesis which can inhibit the growth of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) (MIC90s: 2 μg/ mL) for both MRSA and MSSA.

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Targocil Chemical Structure
Targocil, CAS 1200443-21-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 50.00
2 mg In stock $ 80.00
5 mg In stock $ 143.00
10 mg In stock $ 215.00
25 mg In stock $ 386.00
50 mg In stock $ 573.00
100 mg In stock $ 822.00
200 mg In stock $ 1,130.00
500 mg In stock $ 1,690.00
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Purity: 99.1%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Targocil is used as a bacteriostatic inhibitor of wall teichoic acid (WTA) biosynthesis which can inhibit the growth of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) (MIC90s: 2 μg/ mL) for both MRSA and MSSA.
Targets&IC50 MRSA:2 μg/mL (MIC90), MSSA:2 μg/mL (MIC90)
In vitro Targocil can inhibit the growth of S. aureus strains Newman, MG2375, MW2, and MG2389 (MICs: 1 μg/mL). Targocil has obviously activity against S. aureus isolates from suspected cases of bacterial keratitis, including both MSSA and MRSA isolates (MICs: 1-2 μg/ mL). Compare to the vehicle alone, Targocil (5 μg/mL) exhibits little toxicity for HCECs, even after 24 h of exposure. However, 40 μg/mL Targocil shows toxicity at all time points tested. In the presence of HCECs, Targocil at levels equal to 10×MIC in vitro readily inhibits the growth of MG2375 and Newman.
Molecular Weight 475.95
Formula C21H22ClN5O4S
CAS No. 1200443-21-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Slightly soluble

TargetMolReferences and Literature

1. Suzuki T, et al. In vitro antimicrobial activity of wall teichoic acid biosynthesis inhibitors against Staphylococcus aureus isolates. Antimicrob Agents Chemother. 2011 Feb;55(2):767-74.

TargetMolCitations

1. Lu Y, Chen F, Zhao Q, et al.Modulation of MRSA virulence gene expression by the wall teichoic acid enzyme TarO.Nature Communications.2023, 14(1): 1594.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Bacterial Compound Library Drug-induced Liver Injury (DILI) Compound Library Bioactive Compound Library Antibiotics Library Inhibitor Library Anti-Infection Compound Library NO PAINS Compound Library Bioactive Compounds Library Max

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Keywords

Targocil 1200443-21-5 Microbiology/Virology Antibacterial inhibit Bacterial Inhibitor inhibitor

 

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