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TTP 22

Catalog No. T1828 CAS 329907-28-0

TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM, and shows selectivity <250-fold for CK2 over JNK3, ROCK1, and MET(IC50< 10 uM).

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TTP 22, CAS 329907-28-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
5 mg	In stock	$ 74.00
10 mg	In stock	$ 112.00
25 mg	In stock	$ 233.00
50 mg	In stock	$ 346.00
100 mg	In stock	$ 513.00
1 mL * 10 mM (in DMSO)	In stock	$ 100.00

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Purity: 97.78%

Purity: 97.08%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM, and shows selectivity >250-fold for CK2 over JNK3, ROCK1, and MET(IC50> 10 uM).
Targets&IC50	CK2:0.1 μM
Kinase Assay	PI3K biochemical assay (ATP depletion assay): BKM120 is dissolved in DMSO and directly distributed into a black 384-well plate at 1.25 μL per well. To start the reaction, 25 μL of 10 nM PI3 kinase and 5 μg/mL 1-α-phosphatidylinositol (PI) in assay buffer (10 mM Tris pH 7.5, 5 mM MgCl2, 20 mM NaCl, 1 mM DTT and 0.05% CHAPS) are added into each well followed by 25 μL of 2 μM ATP in assay buffer. The reaction is performed until approx 50% of the ATP is depleted and then stopped by the addition of 25 μL of KinaseGlo solution. The stopped reaction is incubated for 5 minutes and the remaining ATP is then detected via luminescence.

Molecular Weight	330.42
Formula	C16H14N2O2S2
CAS No.	329907-28-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (151.32 mM)

References and Literature

1. Golub AG, et al. Eur J Med Chem. 2011 Mar;46(3): 870-6.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Metabolism Disease Compound Library Kinase Inhibitor Library Bioactive Compound Library Stem Cell Differentiation Compound Library Wnt/Hedgehog/Notch Compound Library Target-Focused Phenotypic Screening Library Bioactive Compounds Library Max NO PAINS Compound Library Anti-Aging Compound Library

Related Products

Related compounds with same targets

Casein kinase 1δ-IN-8 CK1-IN-3 PF-4800567 CKI-7 free base CKI-7 XL413 SSTC3 AS-252424

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Keywords

TTP 22 329907-28-0 Metabolism Stem Cells Casein Kinase TTP-22 Inhibitor inhibit TTP22 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.