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TASIN-1 Hydrochloride

TASIN-1 Hydrochloride
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TASIN-1 Hydrochloride

Catalog No. T24855Cas No. 1678515-13-3
TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$119In Stock
5 mg$243In Stock
10 mg$345In Stock
25 mg$589In Stock
50 mg$839In Stock
100 mg$1,160In Stock
500 mg$2,330In Stock
1 mL x 10 mM (in DMSO)$256In Stock
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Product Introduction

TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.
In vivo
In nude mice with established DLD1 and HT29 tumors, intraperitoneal injection of TASIN-1 twice daily for 18 days reduced the size of tumor xenografts and tumor growth rates. TASIN-1 resulted in the appearance of apoptotic cells with fragmented nuclei and induced an increase in cleaved caspase 3 and cleaved PARP1. However, TASIN-1 did not inhibit tumor growth in HCT116 xenografts. In a genetically engineered CRC mouse model, TASIN-1 significantly reduced tumor formation in the colons of CPC [1].
Chemical Properties
Molecular Weight388.95
Cas No.1678515-13-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 55 mg/ml (141.41 mM)
Solution Preparation Table
1 mM2.5710 mL12.8551 mL25.7102 mL128.5512 mL
5 mM0.5142 mL2.5710 mL5.1420 mL25.7102 mL
10 mM0.2571 mL1.2855 mL2.5710 mL12.8551 mL
20 mM0.1286 mL0.6428 mL1.2855 mL6.4276 mL
50 mM0.0514 mL0.2571 mL0.5142 mL2.5710 mL
100 mM0.0257 mL0.1286 mL0.2571 mL1.2855 mL


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