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TASIN-1 Hydrochloride

Catalog No. T24855   CAS 1678515-13-3
Synonyms: TASIN 1 Hydrochloride, TASIN 1 HCl, 塔辛-1盐酸盐, TASIN1 Hydrochloride, TASIN-1 HCl, TASIN1 HCl

TASIN-1 Hydrochloride is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.

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TASIN-1 Hydrochloride, CAS 1678515-13-3
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description TASIN-1 Hydrochloride is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.
Targets&IC50 APC:70 nM(DLD1 cells)
In vivo In nude mice with established DLD1 and HT29 tumors, intraperitoneal injection of TASIN-1 twice daily for 18 days reduced the size of tumor xenografts and tumor growth rates. TASIN-1 resulted in the appearance of apoptotic cells with fragmented nuclei and induced an increase in cleaved caspase 3 and cleaved PARP1. However, TASIN-1 did not inhibit tumor growth in HCT116 xenografts. In a genetically engineered CRC mouse model, TASIN-1 significantly reduced tumor formation in the colons of CPC [1].
Synonyms TASIN 1 Hydrochloride, TASIN 1 HCl, 塔辛-1盐酸盐, TASIN1 Hydrochloride, TASIN-1 HCl, TASIN1 HCl
Molecular Weight 388.95
Formula C18H29ClN2O3S
CAS No. 1678515-13-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 55 mg/ml (141.41 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Bai R L, Pettit G R, Hamel E. Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. Journal of Biological Chemistry, 1990, 265(28): 17141-17149. 2. Zhang L, Kim SB, Luitel K, Shay JW. Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells. Mol Cancer Ther. 2018 May;17(5):943-951. 3. Zhang L, Theodoropoulos PC, Eskiocak U, Wang W, Moon YA, Posner B, Williams NS, Wright WE, Kim SB, Nijhawan D, De Brabander JK, Shay JW. Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer. Sci Transl Med. 2016 Oct 19;8(361):361ra140. PubMed PMID: 27798265. 4. Cully M. Anticancer drugs: Exploiting a weakness in colorectal cancers. Nat Rev Drug Discov. 2016 Nov 29;15(12):820-821.

Related Products

Related compounds with same targets
Activated Protein C (390-404), human acetate Apcin TAME Apcin A HCL TASIN-1 Hydrochloride TASIN-1 TAME hydrochloride

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Keywords

TASIN-1 Hydrochloride 1678515-13-3 细胞周期 APC TASIN 1 Hydrochloride TASIN 1 HCl TASIN1 HCl TASIN-1 HCl TASIN1 Hydrochloride Inhibitor inhibitor inhibit