Powder: -20°C for 3 years
In solvent: -80°C for 2 years
TASIN-1 Hydrochloride is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.
Description | TASIN-1 Hydrochloride is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells. |
Targets&IC50 | APC:70 nM(DLD1 cells) |
In vivo | In nude mice with established DLD1 and HT29 tumors, intraperitoneal injection of TASIN-1 twice daily for 18 days reduced the size of tumor xenografts and tumor growth rates. TASIN-1 resulted in the appearance of apoptotic cells with fragmented nuclei and induced an increase in cleaved caspase 3 and cleaved PARP1. However, TASIN-1 did not inhibit tumor growth in HCT116 xenografts. In a genetically engineered CRC mouse model, TASIN-1 significantly reduced tumor formation in the colons of CPC [1]. |
Synonyms | TASIN 1 Hydrochloride, TASIN 1 HCl, 塔辛-1盐酸盐, TASIN1 Hydrochloride, TASIN-1 HCl, TASIN1 HCl |
Molecular Weight | 388.95 |
Formula | C18H29ClN2O3S |
CAS No. | 1678515-13-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 55 mg/ml (141.41 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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TASIN-1 Hydrochloride 1678515-13-3 细胞周期 APC TASIN 1 Hydrochloride TASIN 1 HCl TASIN1 HCl TASIN-1 HCl TASIN1 Hydrochloride Inhibitor inhibitor inhibit