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Salicyl-AMS

Catalog No. T17176   CAS 863238-55-5

Salicyl-AMS is an inhibitor of mycobacterium auxin biosynthesis that inhibits the growth of mycobacterium in the presence of iron deficiency in vitro.

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Salicyl-AMS Chemical Structure
Salicyl-AMS, CAS 863238-55-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 187.00
5 mg In stock $ 587.00
10 mg In stock $ 839.00
25 mg In stock $ 1,280.00
50 mg In stock $ 1,720.00
100 mg In stock $ 2,330.00
500 mg In stock $ 4,660.00
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Purity: 99.92%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Salicyl-AMS is an inhibitor of mycobacterium auxin biosynthesis that inhibits the growth of mycobacterium in the presence of iron deficiency in vitro.
In vitro Salicyl-AMS is a potent inhibitor of salicylate adenylation enzymes used in bacterial siderophore biosynthesis and a promising lead compound for the treatment of tuberculosis.[1]
In vivo The mycobactin biosynthesis inhibitor Salicyl-AMS adenosine] inhibits M. tuberculosis growth in vitro under iron-limited conditions. We conducted a single-dose pharmacokinetic study and a monotherapy study of Salicyl-AMS with mice. Intraperitoneal injection yielded much better pharmacokinetic parameter values than oral administration did. Monotherapy of Salicyl-AMS at 5.6 or 16.7 mg/kg significantly inhibited M. tuberculosis growth in the mouse lung.[2]
Molecular Weight 466.43
Formula C17H18N6O8S
CAS No. 863238-55-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 81.5 mg/mL (174.6 mM)

TargetMolReferences and Literature

1. Citrome L. Cariprazine: chemistry, pharmacodynamics, pharmacokinetics, and metabolism, clinical efficacy, safety, and tolerability. Expert Opin Drug Metab Toxicol. 2013;9(2):193-206. 2. Lun S, et al. Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice. Antimicrob Agents Chemother. 2013;57(10):5138-5140. 3. Ferreras JA, et al. Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis. Nat Chem Biol. 2005;1(1):29-32.

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Keywords

Salicyl-AMS 863238-55-5 Microbiology/Virology Antibacterial SalicylAMS Salicyl AMS inhibitor inhibit

 

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