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SR144528

SR144528
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Purity:99.6%
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SR144528

Catalog No. T16928Cas No. 192703-06-3
SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM).
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
Pack SizePriceAvailabilityQuantity
1 mg$36In Stock
5 mg$87In Stock
10 mg$157In Stock
25 mg$357In Stock
50 mg$533In Stock
100 mg$769In Stock
1 mL x 10 mM (in DMSO)$96In Stock
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Product Introduction

Bioactivity
Description
SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM).
In vitro
SR144528(1 μM) stimulates the forskolin-sensitive adenylyl cyclase activity in CHO-CB2 cells in a concentration-dependent manner with an EC50 of 26 nM[1]. In Raw 264.7 macrophages, SR144528 reduces the activity of caspase 3. SR144528(10 μM) inhibits microsomal ACAT activity(68%)[2].
In vivo
SR144528 enhances delayedgastric emptying[3].
Chemical Properties
Molecular Weight476.05
FormulaC29H34ClN3O
Cas No.192703-06-3
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 45.0 mg/mL (94.5 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1006 mL10.5031 mL21.0062 mL105.0310 mL
5 mM0.4201 mL2.1006 mL4.2012 mL21.0062 mL
10 mM0.2101 mL1.0503 mL2.1006 mL10.5031 mL
20 mM0.1050 mL0.5252 mL1.0503 mL5.2515 mL
50 mM0.0420 mL0.2101 mL0.4201 mL2.1006 mL

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