Powder: -20°C for 3 years
In solvent: -80°C for 2 years
SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM).
Description | SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM). |
Targets&IC50 | CB2 receptor:0.6 nM(ki) |
In vitro | SR144528(1 μM) stimulates the forskolin-sensitive adenylyl cyclase activity in CHO-CB2 cells in a concentration-dependent manner with an EC50 of 26 nM[1]. In Raw 264.7 macrophages, SR144528 reduces the activity of caspase 3. SR144528(10 μM) inhibits microsomal ACAT activity(68%)[2]. |
In vivo | SR144528 enhances delayedgastric emptying[3]. |
Molecular Weight | 476.05 |
Formula | C29H34ClN3O |
CAS No. | 192703-06-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 45.0 mg/mL (94.5 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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SR144528 192703-06-3 GPCR/G Protein Cannabinoid Receptor SR-144528 Inhibitor inhibitor inhibit