Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SEC activates ANXA7 GTPase through the AMPK/mTORC1/STAT3 signaling pathway. It selectively induces apoptosis in cancer cells expressing high levels of ITGB4 by promoting ITGB4 nuclear translocation [1][2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 6-8 weeks | $ 297.00 | |
25 mg | 6-8 weeks | $ 985.00 | |
50 mg | 6-8 weeks | $ 1,280.00 | |
100 mg | 6-8 weeks | $ 1,860.00 |
Description | SEC activates ANXA7 GTPase through the AMPK/mTORC1/STAT3 signaling pathway. It selectively induces apoptosis in cancer cells expressing high levels of ITGB4 by promoting ITGB4 nuclear translocation [1][2]. |
In vitro | SEC (20 μM) inhibits the cell migration of HEK 293T RKIP-/- cells and PC3 prostate cancer cells[1].SEC (20 μM) significantly increases AMPK phosphorylation in PC3 cells, which is inverted by ANXA7 GTPase specific inhibitor ABO, indicating that activated ANXA7 with enhanced phosphorylation level promotes AMPK phosphorylation (cell selectively)[1]. Cell Viability Assay[1] Cell Line: HEK293T RKIP-/- cells.[1] |
In vivo | SEC (3 mg/kg/day or 18 mg/kg/day) suppresses metastasis in PC-3M-Luc orthotopic implantation nude mice model[1]. Animal Model: Luciferase-labeled PC-3M-Luc cells (2×106 per 50 μL sterile HBSS-/-) are orthotopically inoculated into the prostates of 8-week-old nude mice[1]. |
Molecular Weight | 430.88 |
Formula | C22H23ClN2O5 |
CAS No. | 1802997-81-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SEC 1802997-81-4 inhibitor inhibit