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S-5751

Catalog No. T28651 CAS 209268-36-0

Synonyms: S 5751

S-5751, a prostanoid DP (DP1) antagonist, is used potentially for the treatment of bronchial asthma.

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S-5751, CAS 209268-36-0

Pack Size	Availability	Price/USD
5 mg	6-8 weeks	$ 1,070.00 $ 856.00
50 mg	6-8 weeks	$ 2,180.00 $ 1,744.00
100 mg	6-8 weeks	$ 2,800.00 $ 2,240.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

S-5751, a prostanoid DP (DP1) antagonist, is used potentially for the treatment of bronchial asthma.

Synonyms	S 5751
Molecular Weight	441.58
Formula	C25H31NO4S
CAS No.	209268-36-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Arimura A, Yasui K, Kishino J, Asanuma F, Hasegawa H, Kakudo S, Ohtani M, Arita H. Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, S-5751. J Pharmacol Exp Ther. 2001 Aug;298(2):411-9. PubMed PMID: 11454901. 2. Shichijo M, Arimura A, Hirano Y, Yasui K, Suzuki N, Deguchi M, Abraham WM. A prostaglandin D2 receptor antagonist modifies experimental asthma in sheep. Clin Exp Allergy. 2009 Sep;39(9):1404-14. doi: 10.1111/j.1365-2222.2009.03275.x. PubMed PMID: 19486034. 3. Hirano Y, Shichijo M, Ikeda M, Kitaura M, Tsuchida J, Asanuma F, Yanagimoto T, Furue Y, Imura K, Yasui K, Arimura A. Prostanoid DP receptor antagonists suppress symptomatic asthma-like manifestation by distinct actions from a glucocorticoid in rats. Eur J Pharmacol. 2011 Sep;666(1-3):233-41. doi: 10.1016/j.ejphar.2011.05.003. PubMed PMID: 21596028. 4. Yasui K, Asanuma F, Hirano Y, Shichijo M, Deguchi M, Arimura A. Contribution of prostaglandin D2 via prostanoid DP receptor to nasal hyperresponsiveness in guinea pigs repeatedly exposed to antigen. Eur J Pharmacol. 2008 Jan 14;578(2-3):286-91. PubMed PMID: 17927976.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

S-5751 209268-36-0 S 5751 S5751 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.