Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rotigaptide is a novel and specific modulator of Cx43 and is a potent AAP. Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress.
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25 mg | Inquiry | $ 954.00 |
Description | Rotigaptide is a novel and specific modulator of Cx43 and is a potent AAP. Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. |
In vitro | Rotigaptide (100 nM; 24 hours) does not affect INS-1 cell apoptosis itself. Rotigaptide (100 nM; 24 hours) has a positive effect on the cycloheximide-mediated decrease in Cx43 protein levels in cultured neonatal ventricular myocytes. And it obviously decreases apoptosis in cytokine-exposed cells ~10% at IL-1b concentrations above 15 pg/ml in rat insulin-producing INS-1 cells [1][2]. |
In vivo | Rotigaptide (intravenous administration; 300 mg/kg; single dose) treatment in mice and rats does not cause toxicity in either species. Rotigaptide (continuous intravenous infusion; 5-14 days) in rats (100 mg/kg) and dogs (10 mg/kg) is well tolerated and produces no compound-related effects or histological toxicological findings in escalating dose studies [3]. |
Synonyms | ZP123 |
Molecular Weight | 617.65 |
Formula | C28H39N7O9 |
CAS No. | 355151-12-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Rotigaptide 355151-12-1 Others ZP-123 ZP123 ZP 123 inhibitor inhibit