Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ro 15-2041 is a selective inhibitor of platelet phosphodiesterase, with antithrombotic properties.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,670.00 | |
50 mg | 6-8 weeks | $ 2,180.00 | |
100 mg | 6-8 weeks | $ 2,800.00 |
Description | Ro 15-2041 is a selective inhibitor of platelet phosphodiesterase, with antithrombotic properties. |
In vitro | Ro 15-2041 inhibits platelet aggregation induced by all common platelet agonists in platelet-rich plasma obtained from various species including man with IC50 of 1-3 μM. It potentiates platelet inhibition by prostacyclin, the prostacyclin-induced increase of intraplatelet cyclic (c) AMP levels and inhibits the collagen-induced release of serotonin and beta-thromboglobulin. Ro 15-2041 reduces the increase and accelerated the normalization of cytosolic free Ca2+ in thrombin-stimulated human platelets. Ro 15-2041 is a potent (IC50=70 nM) and selective inhibitor of platelet cAMP-phosphodiesterase activity. |
Molecular Weight | 294.15 |
Formula | C12H12BrN3O |
CAS No. | 77448-87-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Ro-15-2041 77448-87-4 Others Ro152041 Ro 15 2041 inhibitor inhibit