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Rituximab

Catalog No. T9910 CAS 174722-31-7

Synonyms: Rituximab (anti-CD20), anti-CD20, IDEC-C2B8

Rituximab anti-CD20) is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Rituximab, CAS 174722-31-7

Pack Size	Availability	Price/USD
1 mg	In stock	229.00
5 mg	In Stock	544.00
25 mg	In stock	2070.00
50 mg	In stock	3307.00

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Purity 99.9%

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Purity 10mg/ml

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Biological Description

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Storage & Solubility Information

Description	Rituximab anti-CD20) is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM.
Targets&IC50	CD20
Cell Research	Objective: Complement-mediated cell lysis Concentrations: 0, 0.02, 0.2, 2, 20 μg/mL Incubation Time: 2 h Method: Lymphoma B cells were purified from lymph node biopsies of patients with B-cell lymphoma. Rituximab was added to tumor cells (1×106 /mL) in complete medium supplemented by human serum, inactivated or not by incubation at 56°C for 30 minutes. After 2 hours at 37°C, cell lysis was determined by PI staining of cells and analysis by flow cytometry. Cell lines: Lymphoma B cells
Animal Research	Objective: To investigate the therapeutic effect of rituximab in combination with L19-IL2 on B-cell malignancies Formulation: saline Dosages: 200 μg

Synonyms	Rituximab (anti-CD20) , anti-CD20 , IDEC-C2B8
Purity	99.9%
Molecular Weight	148000
CAS No.	174722-31-7

Storage

Store the unopened solution at -20℃, and store it at 4℃ after melting to avoid repeated freeze-thaw

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Du J, et al. Structural basis for recognition of CD20 by therapeutic antibody Rituximab. J Biol Chem. 2007 May 18;282(20). 2. George J. et al. Rituximab: mechanism of action.Semin Hematol. 2010 April ; 47(2): 115–123. 3. Chow KU, et al. Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: role of cytokines, complement, and caspases. Haematologica. 2002 Jan;87(1):33-43. 4. Schliemann C, et al. Complete eradication of human B-cell lymphoma xenografts using rituximab in combination with the immunocytokine L19-IL2. Blood. 2009 Mar 5;113(10):2275-83. 5. Cartron G, et al. Pharmacokinetics of rituximab and its clinical use: thought for the best use Crit Rev Oncol Hematol. 2007 Apr;62(1):43-52.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.