Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Quinacainol (RP 54272) is a new antiarrhythmic compound with class I antiarrhythmic effects in rats.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 143.00 | |
5 mg | In stock | $ 360.00 | |
10 mg | In stock | $ 530.00 | |
25 mg | In stock | $ 859.00 | |
50 mg | In stock | $ 1,180.00 | |
100 mg | In stock | $ 1,590.00 |
Description | Quinacainol (RP 54272) is a new antiarrhythmic compound with class I antiarrhythmic effects in rats. |
In vitro | Quinacainol blocked sodium currents in a concentration-dependent manner and with a potency similar to that of quinidine (mean (+/-SEM) EC50 50+/-12 vs 95+/-25 micromol/L for quinidine and quinacainol, respectively). Quinacainol, a quinidine analog, blocks sodium currents in cardiac myocytes with little effect on I (to) or iKsus potassium currents, which suggests that quinacainol may be exerting class 1c anti-arrhythmic actions.[1] |
In vivo | Evaluation of antiarrhythmic effects using Quinacainol in conscious rats with LAD coronary artery occlusion. Antiarrhythmic actions occurred with 2.0 and 4.0 mg/kg, whereas 8.0 mg/kg was pro-arrhythmic. At doses of 0.5 mg/kg and above, quinacainol increased threshold currents for capture and for ventricular fibrillation. Doses of 2.0 mg/kg and above increased ventricular refractoriness. From 1.0 to 8.0 mg/kg, quinacainol reduced dV/dtmax of phase 0 of epicardial action potentials but only 8.0 mg/kg increased action potential duration. The Q-T interval was also increased with the highest dose. Quinacainol dose-relatedly increased P-R interval whereas QRS did not change. Thus the Class I electrophysiological properties of quinacainol over the dose range tested did not fit accurately into a single subclass of the various subclasses of Class I. However, the Class Ic actions seen with 2.0 and 4.0 mg/kg were associated with antiarrhythmic actions.[2] |
Synonyms | PK-10139, RP-54272, RP 54272, PK 10139, PK10139 |
Molecular Weight | 326.48 |
Formula | C21H30N2O |
CAS No. | 86073-85-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (153.15 mM)
You can also refer to dose conversion for different animals. More
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Quinacainol 86073-85-0 Others PK-10139 RP-54272 RP 54272 PK 10139 RP54272 PK10139 inhibitor inhibit