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OTSSP167

Catalog No. T1759   CAS 1431697-89-0
Synonyms: MELK inhibitor, OTS167

OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.

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OTSSP167 Chemical Structure
OTSSP167, CAS 1431697-89-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 47.00
5 mg In stock $ 80.00
10 mg In stock $ 122.00
25 mg In stock $ 197.00
50 mg In stock $ 297.00
100 mg In stock $ 455.00
500 mg In stock $ 987.00
1 mL * 10 mM (in DMSO) In stock $ 97.00
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Purity: 99.47%
Purity: 98.37%
Purity: 98.22%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.
Targets&IC50 MELK:0.41 nM
Kinase Assay in vitro kinase assay: MELK recombinant protein (0.4 μg) is mixed with 5 μg of each substrate in 20 μL of kinase buffer containing 30 mM Tris-HCl (pH), 10 mM DTT, 40 mM NaF, 10 mM MgCl2, 0.1 mM EGTA with 50 μM cold-ATP and 10 Ci of [γ-32P]ATP for 30 min at 30 °C. The reaction is terminated by addition of SDS sample buffer and boiled for 5 min prior to SDS-PAGE. The gel is dried and autoradiographed with intensifying screens at room temperature. OTSSP167 (final concentration of 10 nM) is dissolved in DMSO and added to kinase buffer before the incubation.
Cell Research Cell Counting Kit-8(Only for Reference)
Synonyms MELK inhibitor, OTS167
Molecular Weight 487.42
Formula C25H28Cl2N4O2
CAS No. 1431697-89-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7.22 mg/ml (14.82 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Chung S, et al. Oncotarget, 2012, 3(12), 1629-1640. 2. Müller HD, et al. J Endod. 2012, 38(11), 1498-1503. 3. Tang Q, Li W, Zheng X, et al. MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma[J]. Signal Transduction and Targeted Therapy. 2020, 5(1): 1-12.

TargetMolCitations

1. Tang Q, Li W, Zheng X, et al. MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma. Signal Transduction and Targeted Therapy. 2020, 5(1): 1-12.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Hematonosis Compound Library Anti-Metabolism Disease Compound Library HIF-1 Signaling Pathway Compound Library Preclinical Compound Library Cancer Cell Differentiation Compound Library Inhibitor Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets
HTH-01-091 MELK-IN-1 NMS-P715 MELK-8a Dihydrochloride MELK-8a hydrochloride JTV-519 hemifumarate Antitumor agent-116 OTSSP167 hydrochloride

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Keywords

OTSSP167 1431697-89-0 PI3K/Akt/mTOR signaling MELK MELK inhibitor inhibit Maternal embryonic leucine zipper kinase Inhibitor OTS-167 OTSSP 167 OTS 167 OTS167 OTSSP-167 inhibitor

 

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