Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 47.00 | |
5 mg | In stock | $ 80.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 197.00 | |
50 mg | In stock | $ 297.00 | |
100 mg | In stock | $ 455.00 | |
500 mg | In stock | $ 987.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity. |
Targets&IC50 | MELK:0.41 nM |
Kinase Assay | in vitro kinase assay: MELK recombinant protein (0.4 μg) is mixed with 5 μg of each substrate in 20 μL of kinase buffer containing 30 mM Tris-HCl (pH), 10 mM DTT, 40 mM NaF, 10 mM MgCl2, 0.1 mM EGTA with 50 μM cold-ATP and 10 Ci of [γ-32P]ATP for 30 min at 30 °C. The reaction is terminated by addition of SDS sample buffer and boiled for 5 min prior to SDS-PAGE. The gel is dried and autoradiographed with intensifying screens at room temperature. OTSSP167 (final concentration of 10 nM) is dissolved in DMSO and added to kinase buffer before the incubation. |
Cell Research | Cell Counting Kit-8(Only for Reference) |
Synonyms | MELK inhibitor, OTS167 |
Molecular Weight | 487.42 |
Formula | C25H28Cl2N4O2 |
CAS No. | 1431697-89-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 7.22 mg/ml (14.82 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
OTSSP167 1431697-89-0 PI3K/Akt/mTOR signaling MELK MELK inhibitor inhibit Maternal embryonic leucine zipper kinase Inhibitor OTS-167 OTSSP 167 OTS 167 OTS167 OTSSP-167 inhibitor