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OTS964

Catalog No. T61800 CAS 1338542-14-5

OTS964 is a potent, orally active compound that operates as a highly selective inhibitor of TOPK with an IC 50 of 28 nM [1]. Additionally, it demonstrates significant inhibitory action against cyclin-dependent kinase CDK11, specifically binding to CDK11B with a K d of 40 nM [2].

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OTS964, CAS 1338542-14-5

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,520.00
50 mg	8-10 weeks	$ 1,980.00
100 mg	8-10 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

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Description	OTS964 is a potent, orally active compound that operates as a highly selective inhibitor of TOPK with an IC 50 of 28 nM [1]. Additionally, it demonstrates significant inhibitory action against cyclin-dependent kinase CDK11, specifically binding to CDK11B with a K d of 40 nM [2].
In vitro	OTS964 treatment at a concentration of 10 nM for 48 hours has been shown to effectively suppress the proliferation of cancer cells and increase cancer cell death in LU-99 cells, as reported in study [1]. Moreover, when OTS964 is administered to Hs683 and H4 cells at varying concentrations (0.1, 1, and 2 μM) for 24 and 48 hours, it significantly upregulates the expression of LC3-II and downregulates P62 expression in a dose-dependent manner, as demonstrated in study [3]. This indicates OTS964's strong potential in inducing autophagy and promoting apoptotic processes in cancer cells.
In vivo	OTS964, administered intravenously at a dosage of 40 mg/kg on days 1, 4, 8, 11, 15, and 18, leads to continuous tumor shrinkage post-treatment, culminating in complete regression in nude mice bearing LU-99 lung cancer cells [1]. Similarly, oral administration of OTS964 at daily doses of 50 or 100 mg/kg for two weeks results in complete tumor regression in the same animal model [1]. These findings highlight the efficacy of OTS964 in inducing complete regression of LU-99 lung cancer cells in nude mice, regardless of the route of administration.

Molecular Weight	392.51
Formula	C23H24N2O2S
CAS No.	1338542-14-5

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

OTS964 1338542-14-5 inhibitor inhibit

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