Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nicodicosapent is a fatty acid niacin conjugate. It is also an inhibitor of the sterol regulatory element-binding protein (SREBP). The sterol regulatory element-binding protein (SREBP) is a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 94.00 | |
25 mg | 6-8 weeks | $ 690.00 | |
50 mg | 6-8 weeks | $ 897.00 | |
100 mg | 6-8 weeks | $ 1,490.00 |
Description | Nicodicosapent is a fatty acid niacin conjugate. It is also an inhibitor of the sterol regulatory element-binding protein (SREBP). The sterol regulatory element-binding protein (SREBP) is a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1. |
In vitro | Nicodicosapent obviously suppresses ApoB secretion in a dose-dependent manner (IC50: 27 μM). Nicodicosapent displays a synergistic inhibition on secreted PCSK9 ( IC50: 17 μM). Nicodicosapent reduces the production of mature SREBP-2 protein in HepG2 cells but does not interact with the GPR109A receptor. Nicodicosapent causes time-dependent hydrolysis in HepG2 cells. |
In vivo | Nicodicosapent (100 mg/kg p.o.) produces high plasma levels of nicotinic acid in the plasma. ApoE*3-Leiden mice treated with Nicodicosapent display an obvious reduction in PCSK9 levels, LDL particles including VLDL and LDL cholesterol, and plasma triglycerides. |
Molecular Weight | 449.63 |
Formula | C28H39N3O2 |
CAS No. | 1269181-69-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (222.41 mM)
You can also refer to dose conversion for different animals. More
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Nicodicosapent 1269181-69-2 Others inhibitor inhibit