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Napsagatran hydrate

Catalog No. T16273 CAS 159668-20-9

Synonyms: Ro 46-6240/010 hydrate, Ro 46-6240 hydrate

Napsagatran hydrate is a novel and specific inhibitor of thrombin.

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Napsagatran hydrate, CAS 159668-20-9

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 2,270.00
50 mg	10-14 weeks	$ 2,980.00
100 mg	10-14 weeks	$ 4,000.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Napsagatran hydrate is a novel and specific inhibitor of thrombin.
In vitro	Napsagatran causes a dose-dependent prolongation of the activated partial thromboplastin time (aPTT) and prothrombin time (PT) that is evident 15 min after administration of the bolus of Napsagatran. Napsagatran also reduces the time to reperfusion in a dose-dependent manner and delays or prevents reocclusion. The decreasing intracellular amount and efflux of the compound from the cells into the medium is measured [1][2].
In vivo	Statistical analysis confirms that thrombus growth in the placebo and AP-1 treated rabbits is not different. In contrast, the reduction of 125I-fibrinogen incorporation by Napsagatran is statistically different from the placebo group (P<0.01). After the first hour of drug administration (from 0 to 60 min), the incorporated radioactivity into thrombi increased from baseline by 73±13, 67±22, and 32±10% in placebo, AP-1, and Napsagatran-treated rabbits, respectively.[3].

Synonyms	Ro 46-6240/010 hydrate, Ro 46-6240 hydrate
Molecular Weight	576.67
Formula	C26H36N6O7S
CAS No.	159668-20-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Pratico D, et al. Interaction of a thrombin inhibitor and a platelet GP IIb/IIIa antagonist in vivo: evidence thatthrombin mediates platelet aggregation and subsequent thromboxane A2 formation during coronary thrombolysis. J Pharmacol Exp Ther. 1997 Jun;281(3):1178-85. 2. Lundquist P, et al. Prediction of in vivo rat biliary drug clearance from an in vitro hepatocyte efflux model. Drug Metab Dispos. 2014 Mar;42(3):459-68. 3. Himber J, et al. Inhibition of tissue factor limits the growth of venous thrombus in the rabbit. J Thromb Haemost. 2003 May;1(5):889-95.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Napsagatran hydrate 159668-20-9 Others Ro 46-6240 Hydrate Ro 46-6240/010 hydrate Ro 46-6240 hydrate Napsagatran Hydrate Ro 46-6240/010 Hydrate inhibitor inhibit

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