Powder: -20°C for 3 years | In solvent: -80°C for 2 years
MRT00033659 is an effective broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and Chk1 (IC50=0.23 μM). MRT00033659 is a pyrazolo-pyridine analogue. It also induces p53 pathway activation and E2F-1 destabilization.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | 6-8 weeks | Inquiry | |
100 mg | 6-8 weeks | Inquiry |
Description | MRT00033659 is an effective broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM). MRT00033659 is a pyrazolo-pyridine analogue. It also induces p53 pathway activation and E2F-1 destabilization. |
Targets&IC50 | Chk1:0.23 μM, CKIδ:0.9 μM |
In vitro | MRT00033659 does not inhibit p38α MAPK. MRT00033659 (1-80 μM; 48 hours) causes substantial cell death from 5 μM. MRT00033659 (0.2-80 μM; 48 hours) induces a robust and sustained stabilisation of p53, MDM2, and p21 proteins, as well as E2F-1 destabilisation from 0.2 μM to 5 μM. MRT00033659 (5-40 μM; 48 hours) is sufficient to obviously decrease cell number of 5 μM . |
Molecular Weight | 266.3 |
Formula | C15H14N4O |
CAS No. | 1401731-54-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MRT00033659 1401731-54-1 Others MRT-00033659 inhibitor inhibit