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MRT00033659

Catalog No. T16141 CAS 1401731-54-1

MRT00033659 is an effective broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and Chk1 (IC50=0.23 μM). MRT00033659 is a pyrazolo-pyridine analogue. It also induces p53 pathway activation and E2F-1 destabilization.

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MRT00033659, CAS 1401731-54-1

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50 mg	6-8 weeks	Inquiry
100 mg	6-8 weeks	Inquiry

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Purity: 98%

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Description	MRT00033659 is an effective broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM). MRT00033659 is a pyrazolo-pyridine analogue. It also induces p53 pathway activation and E2F-1 destabilization.
Targets&IC50	Chk1:0.23 μM, CKIδ:0.9 μM
In vitro	MRT00033659 does not inhibit p38α MAPK. MRT00033659 (1-80 μM; 48 hours) causes substantial cell death from 5 μM. MRT00033659 (0.2-80 μM; 48 hours) induces a robust and sustained stabilisation of p53, MDM2, and p21 proteins, as well as E2F-1 destabilisation from 0.2 μM to 5 μM. MRT00033659 (5-40 μM; 48 hours) is sufficient to obviously decrease cell number of 5 μM .

Molecular Weight	266.3
Formula	C15H14N4O
CAS No.	1401731-54-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Huart AS, et al. A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novelactivator of the p53 pathway. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5578-85.

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Keywords

MRT00033659 1401731-54-1 Others MRT-00033659 inhibitor inhibit

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