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ML359

Catalog No. T25821 CAS 1069858-99-6

Synonyms: ML-359, ML 359

ML359 is a protein disulfide isomerase inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

ML359, CAS 1069858-99-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 83.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 332.00
25 mg	In stock	$ 558.00
50 mg	In stock	$ 788.00
100 mg	In stock	$ 1,120.00
1 mL * 10 mM (in DMSO)	In stock	$ 232.00

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Purity: 99.16%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ML359 is a protein disulfide isomerase inhibitor.
Targets&IC50	Protein disulfide isomerase:250 nM (IC50)
In vitro	ML359 shown to be a specific inhibitor of PDI.?ML359 shows no cytotoxicity in three human cell lines, and some activity in inhibiting platelet aggregation in vitro.?ML359 will provide more understanding of the mechanisms of PDI in platelet functions.?It also could lead to the development of a new class of antithrombotics that could establish PDI as suitable drug target.

Synonyms	ML-359, ML 359
Molecular Weight	417.93
Formula	C23H28ClNO4
CAS No.	1069858-99-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 84 mg/mL (200.99 mM)

Ethanol: 84 mg/mL (200.99 mM)

References and Literature

1. Khodier C, VerPlank L, Nag PP, Pu J, Wurst J, Pilyugina T, Dockendorff C, Galinski CN, Scalise AA, Passam F, van Hessem L, Dilks J, Kennedy DR, Flaumenhaft R, Palmer MAJ, Dandapani S, Munoz B, Schrieber SL. Identification of ML359 as a Small Molecule Inhibitor of Protein Disulfide Isomerase. 2013 Apr 12 [updated 2014 Sep 18]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK189925/ PubMed PMID: 24624466.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library NO PAINS Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ML359 1069858-99-6 Others isomerase disulfide Inhibitor inhibit ML-359 PDI thrombus ML 359 protein inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.