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ML314

Catalog No. TQ0075 CAS 1448895-09-7

ML314 is an effective molecule agonist of NTR1 (EC50: 1.9 μM).

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ML314, CAS 1448895-09-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ML314 is an effective molecule agonist of NTR1 (EC50: 1.9 μM).
Targets&IC50	NTR1:1.9 μM (EC50)
In vitro	ML314 showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization. ML314 is potentially a biased agonist operating via the β-arrestin pathway rather than the traditional Gq coupled pathway.

Molecular Weight	420.5
Formula	C24H28N4O3
CAS No.	1448895-09-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 45 mg/mL (107.01 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Hershberger P, et al. Small Molecule Agonists for the Neurotensin 1 Receptor (NTR1 Agonists). Probe Reports from the NIH Molecular Libraries Program

Related Products

Related compounds with same targets

ML314 Urantide acetate(669089-53-6 free base) UFP 803 acetate Substance P 1-9 aceate Neurotensin Kinetensin acetate(103131-69-7 free base) SORT-PGRN interaction inhibitor 1 Neurotensin(8-13) 3TFA(60482-95-3(free base))

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ML314 1448895-09-7 G蛋白偶联受体 Neurotensin Receptor ML-314 Inhibitor inhibitor inhibit

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