Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Libenzapril (CGS 16617) is a potent angiotensin-converting enzyme inhibitor used to study myocardial injury.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 250.00 | |
5 mg | In stock | $ 623.00 | |
10 mg | In stock | $ 887.00 | |
25 mg | In stock | $ 1,330.00 | |
50 mg | In stock | $ 1,780.00 | |
100 mg | In stock | $ 2,430.00 |
Description | Libenzapril (CGS 16617) is a potent angiotensin-converting enzyme inhibitor used to study myocardial injury. |
In vivo | The effect of intravenous (i.v.) libenzapril was studied in six healthy males by administering i.v. angiotensin I (AI) was administered in stepwise increments of 20 ng/kg/5 min until the subjects' systolic blood pressure (SBP) had increased 20-30 mm Hg above baseline. The mean baseline infusion of 63 ng/kg/5 min resulted in a significant (P < 0.05) increase in the ratio of AII to AI plasma levels from 0.52 +/- 0.46 to 7.92 +/- 4.48 and a SBP increase of 120 +/- 7.1 to 147 +/- 5.6. Within 15 minutes of starting the 1-mg infusion of libenzapril over 1.5 hours, the AII/AI ratio decreased to baseline values, and the SBP returned to baseline in 1 hour. Repeat AI challenges at 3.5 and 5 hours postdose did not increase SBP significantly. Even the 6.5-hour challenge demonstrated only a slight increase in SBP, with an AII/AI ratio of 0.26. At 24 hours, SBP was only 40% of the baseline response, demonstrating that libenzapril is a potent long-acting ACE inhibitor.[1] |
Synonyms | CGS 16617, Abutapril |
Molecular Weight | 363.41 |
Formula | C18H25N3O5 |
CAS No. | 109214-55-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Libenzapril 109214-55-3 Metabolism Angiotensin-converting Enzyme (ACE) CGS-16617 CGS 16617 CGS16617 Abutapril inhibitor inhibit