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L 870810

Catalog No. T24366   CAS 410544-95-5
Synonyms: L-870,810, L870810, L 870,810, L870,810, L-870810

L 870810 is a small-molecule inhibitor of HIV-1 integrase with potent antiviral activity in cell culture and good pharmacokinetic properties.

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L 870810 Chemical Structure
L 870810, CAS 410544-95-5
Pack Size Availability Price/USD Quantity
25 mg 6-8 weeks $ 1,670.00
50 mg 6-8 weeks $ 2,180.00
100 mg 6-8 weeks $ 2,800.00
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage & Solubility Information
Description L 870810 is a small-molecule inhibitor of HIV-1 integrase with potent antiviral activity in cell culture and good pharmacokinetic properties.
Synonyms L-870,810, L870810, L 870,810, L870,810, L-870810
Molecular Weight 430.45
Formula C20H19FN4O4S
CAS No. 410544-95-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Markopoulos C, Vertzoni M, Symillides M, Kesisoglou F, Reppas C. Two-Stage Single-Compartment Models to Evaluate Dissolution in the Lower Intestine. J Pharm Sci. 2015 Sep;104(9):2986-97. doi: 10.1002/jps.24485. Epub 2015 May 18. PubMed PMID: 25989323. 2. Petrakis O, Vertzoni M, Angelou A, Kesisoglou F, Bentz K, Goumas K, Reppas C. Identification of key factors affecting the oral absorption of salts of lipophilic weak acids: a case example. J Pharm Pharmacol. 2015 Jan;67(1):56-67. doi: 10.1111/jphp.12320. Epub 2014 Sep 23. PubMed PMID: 25252222. 3. Zeng LF, Wang Y, Kazemi R, Xu S, Xu ZL, Sanchez TW, Yang LM, Debnath B, Odde S, Xie H, Zheng YT, Ding J, Neamati N, Long YQ. Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties. J Med Chem. 2012 Nov 26;55(22):9492-509. doi: 10.1021/jm300667v. Epub 2012 Nov 7. PubMed PMID: 23098137. 4. Low A, Prada N, Topper M, Vaida F, Castor D, Mohri H, Hazuda D, Muesing M, Markowitz M. Natural polymorphisms of human immunodeficiency virus type 1 integrase and inherent susceptibilities to a panel of integrase inhibitors. Antimicrob Agents Chemother. 2009 Oct;53(10):4275-82. doi: 10.1128/AAC.00397-09. Epub 2009 Aug 3. PubMed PMID: 19651917; PubMed Central PMCID: PMC2764199.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

L 870810 410544-95-5 Others L-870,810 L870810 L 870,810 L870,810 L-870810 inhibitor inhibit

 

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