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Kira8 Hydrochloride

Kira8 Hydrochloride
Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
Catalog No. T11762Cas No. 2250019-92-0

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Kira8 Hydrochloride

Catalog No. T11762Cas No. 2250019-92-0

Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
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5 mg$79335 days
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Product Introduction

Bioactivity
Description
Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
Targets&IC50
IRE1α:, IRE1α RNase:5.9 nM
In vitro
Kira8 more effectively diminishes IRE1α-driven apoptosis in INS-1 cells compared to KIRA6 and additionally counteracts XBP1 splicing induced by GNF-2. It inhibits IRE1α oligomerization and significantly reduces IRE1α RNase activity targeting XBP1 and Ins2 RNAs.
In vivo
Male Ins2+/Akita mice are injected i.p. with KIRA8 (50 mg/kg; daily; for 35 days), significant reduction of hyperglycemia become apparent over several weeks. One week treatment of pre-diabetic NODs mice with Kira8 (50 mg/kg; i.p.; once a day) leads to significant reductions in islet XBP1 splicing and TXNIP mRNAs, and preserves Ins1/Ins2, BiP and MANF mRNAs.
AliasAMG-18 Hydrochloride
Chemical Properties
Molecular Weight637.58
FormulaC31H30Cl2N6O3S
Cas No.2250019-92-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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