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Karenitecin

Catalog No. T14703 CAS 203923-89-1

Synonyms: BNP 1350, Cositecan

Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.

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Karenitecin, CAS 203923-89-1

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 1,530.00
50 mg	10-14 weeks	$ 1,990.00
100 mg	10-14 weeks	$ 3,110.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description	Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
In vitro	Karenitecin, a topoisomerase I inhibitor, exhibits potent anti-cancer properties by effectively inhibiting the growth of various human colon cancer cell lines, including COLO205, COLO320, LS174T, SW1398, and WiDr, demonstrated by IC50 values of 2.4 nM, 1.5 nM, 1.6 nM, 2.9 nM, and 3.2 nM, respectively[2]. Furthermore, it not only induces DNA damage in A253 cells at concentrations of 0.01, 0.07, and 0.7 μM but also elevates the levels of cyclin E and cdk2 proteins at 0.07 and 0.7 μM. Significant cell growth inhibition in A253 cells is achieved with IC10, IC50, and IC90 values of 0.01, 0.07, and 0.7 μM after a 2-hour treatment. Additionally, at low concentrations, Karenitecin significantly augments cyclin B/cdc2-associated kinase activity, whereas it slightly diminishes this activity at higher concentrations[1].
In vivo	Karenitecin (1.0 mg/kg daily × 5 i.p.) significantly reduces growth in both parental Pgp-negative xenografts and Pgp-positive xenografts[2]. It demonstrates a maximum growth inhibition of 61% in COLO320 cells and 54% in COLO205 colon cancer cells following i.p. administration at a dosage of 1 mg/kg in mice.

Synonyms	BNP 1350, Cositecan
Molecular Weight	448.59
Formula	C25H28N2O4Si
CAS No.	203923-89-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Yin MB, et al. Characterization of protein kinase chk1 essential for the cell cycle checkpoint after exposure of human head and neck carcinoma A253 cells to a novel topoisomerase I inhibitor BNP1350. Mol Pharmacol. 2000 Mar;57(3):453-9. 2. Van Hattum AH, et al. New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer. Int J Cancer. 2000 Oct 15;88(2):260-6.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Karenitecin 203923-89-1 DNA Damage/DNA Repair Topoisomerase BNP 1350 BNP-1350 BNP1350 Cositecan inhibitor inhibit

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