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K-252b

Catalog No. T15637 CAS 99570-78-2

K-252b is an indolocarbazole isolated from the actinomycete Nocardiopsis and is a <a href="/target/PKC" style="display: inline; color: #c13a36">PKC</a> inhibitor. K-252b can be used to inhibit extracellular kinases of cells in culture because it can’t pass through the cell membrane freely.

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K-252b, CAS 99570-78-2

Pack Size	Availability	Price/USD	Quantity
5 mg	Inquiry	$ 1,378.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

K-252b is an indolocarbazole isolated from the actinomycete Nocardiopsis and is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in culture because it can’t pass through the cell membrane freely.

Molecular Weight	453.45
Formula	C26H19N3O5
CAS No.	99570-78-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Yasuzawa, T., et al. The structures of the novel protein kinase C inhibitors K-252a, b, c AND d Journal of Antibiotics 39(8), 1072-1078 (1986). 2. Plomp, J.J., et al. Involvement of protein kinases in the upregulation of acetylcholine release at endplates of α-bungarotoxin-treated rats Journal of Physiology 493, 175-186 (1996). 3. Zhu, X., et al. Evidence of ectokinase-mediated phosphorylation of osteopontin and bone sialoprotein by osteoblasts during bone formation in vitro Biochemistry Journal 323, 637-643 (1997).

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

K-252b 99570-78-2 Chromatin/Epigenetic Cytoskeletal Signaling PKC K252b K 252b Inhibitor inhibitor inhibit

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