store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Jasplakinolide(Jaspamide), a naturally occurring cyclic peptide from marine sponges, is a potent inducer of actin polymerization.Jasplakinolide exhibits antifungal and antitumor activity and stabilizes pre-existing actin filaments. Jasplakinolide competitively binds to F-actin with the ghost pen cyclic peptide and has a Kd value of 15 nM for F-actin.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 μg | 4-5 weeks | $ 1,170.00 |
Description | Jasplakinolide(Jaspamide), a naturally occurring cyclic peptide from marine sponges, is a potent inducer of actin polymerization.Jasplakinolide exhibits antifungal and antitumor activity and stabilizes pre-existing actin filaments. Jasplakinolide competitively binds to F-actin with the ghost pen cyclic peptide and has a Kd value of 15 nM for F-actin. |
In vitro | Jasplakinolide, at a concentration of 1 mM for 60 minutes, prompts the development of apical extensions rich in actin within fixed Toxoplasma gondii tachyzoites. It exhibits an IC50 of 35 nM against PC3 prostate carcinoma cells, underscoring its potent antiproliferative capability. Additionally, when introduced at 10 μM for 2 hours during mitosis, jasplakinolide leads to the formation of binucleated cells. This compound also triggers the production of F-actin-enriched apical extensions in Toxoplasma gondii tachyzoites, demonstrating its broad impact on cellular architecture.[1][2] |
Synonyms | Jaspamide, NSC-613009 |
Molecular Weight | 709.67 |
Formula | C36H45BrN4O6 |
CAS No. | 102396-24-7 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Jasplakinolide 102396-24-7 Cytoskeletal Signaling Microbiology/Virology Microtubule Associated Antifungal Jaspamide NSC-613009 NSC 613009 NSC613009 inhibitor inhibit