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JTE-907

Catalog No. T19705 CAS 282089-49-0

Synonyms: JTE 907

JTE-907 is a CB2 receptor inverse agonist with high selectivity and oral activity.JTE-907 exhibits anti-inflammatory activity in vivo.

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JTE-907, CAS 282089-49-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
5 mg	In stock	$ 128.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 347.00
50 mg	In stock	$ 516.00
100 mg	In stock	$ 736.00
1 mL * 10 mM (in DMSO)	In stock	$ 153.00

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Purity: 100%

Biological Description

Chemical Properties

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Description

JTE-907 is a CB2 receptor inverse agonist with high selectivity and oral activity.JTE-907 exhibits anti-inflammatory activity in vivo.

In vitro

JTE 907 acts as a Gq-coupled agonist in islets to stimulate insulin secretion and maintain β-cell mass in a GPR55-independent fashion. JTE 907 (10 μM) significantly stimulated insulin secretion from islets isolated from human donors and islets from Gpr55+/+ and Gpr55-/- mice. These stimulatory effects were accompanied by significant elevations of IP1 and [Ca2+]i, but there were no changes in cAMP generation. JTE 907 also significantly reduced cytokine-induced apoptosis in human and mouse islets and promoted human β-cell proliferation.[4]

Synonyms	JTE 907
Molecular Weight	438.47
Formula	C24H26N2O6
CAS No.	282089-49-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 112.5 mg/mL (256.6 mM), Sonication is recommended.

References and Literature

1. Altun A, et al. Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists. J Physiol Sci. 2015;65(5):407-415. 2. Marini P, et al. Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors. Br J Pharmacol. 2013;169(4):887-899. 3. Harvey BS, et al. Cannabinoid CB2 receptor activation attenuates cytokine-evoked mucosal damage in a human colonic explant model without changing epithelial permeability. Cytokine. 2013;63(2):209-217. 4. Ruz-Maldonado I, et al. Direct Stimulatory Effects of the CB2 Ligand JTE 907 in Human and Mouse Islets. Cells. 2021;10(3):700. 5. Ueda Y, et al. Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice. Eur J Pharmacol. 2005;520(1-3):164-171. 6. Maekawa T, et al. The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis. Eur J Pharmacol. 2006;542(1-3):179-183.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Membrane Protein-targeted Compound Library Bioactive Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

CB1 antagonist 1 CB2 modulator 1 Rimonabant Olorinab yangonin CB1 inverse agonist 1 (±)-Ibipinabant Org 27569

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JTE-907 282089-49-0 GPCR/G Protein Cannabinoid Receptor JTE907 JTE 907 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.