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Guadecitabine sodium

Catalog No. T12790 CAS 929904-85-8

Synonyms: SGI-110 sodium, S-110 sodium

Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .

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Guadecitabine sodium, CAS 929904-85-8

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,670.00
50 mg	6-8 weeks	$ 2,180.00
100 mg	6-8 weeks	$ 2,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description	Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .
In vitro	Treatment of HCT116 colorectal carcinoma cells with Guadecitabine sodium (SGI-110 sodium) demonstrated a dose-dependent increase in p16 expression after 6 days. Additionally, there was a similar increase in p16 protein levels in both T24 and HCT116 cells when treated with Guadecitabine sodium or 5-aza-CdR for 3 days. This effect suggests Guadecitabine sodium's effectiveness in inhibiting DNA methylation and stimulating p16 expression at both mRNA and protein levels, akin to 5-aza-CdR. Further, Guadecitabine sodium inhibited DNA methylation in the 5′-region and induced the expression of the p16 gene in T24 and HCT116 cells at concentrations comparable to those of 5-aza-CdR. The induction of p16 expression by both agents was associated with demethylation at the 5′-end region of the gene in both cell lines. In terms of toxicity, Guadecitabine sodium was slightly less toxic than 5-aza-CdR at concentrations up to 1 μM, but displayed similar toxicity levels at 10 μM concentration[1].
In vivo	Guadecitabine sodium (10mg/kg) effectively reduces DNA methylation, retards tumor growth, and demonstrates a toxicity level comparable to 5-Aza-CdR. It successfully reactivates the expression of the heavily methylated p16 gene in parent EJ6 cells and reduces DNA methylation at the p16 promoter region in vivo. Notably, Guadecitabine sodium exhibits better tolerance compared to 5-Aza-CdR in vivo[2].

Synonyms	SGI-110 sodium, S-110 sodium
Molecular Weight	580.407
Formula	C18H24N9NaO10P
CAS No.	929904-85-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (86.30 mM), Sonication is recommended.

H2O: Soluble

References and Literature

1. Yoo CB, et al. Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res. 2007 Jul 1;67(13):6400-8. 2. Chuang JC, et al. S-110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth. Mol Cancer Ther. 2010 May;9(5):1443-50.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Guadecitabine sodium 929904-85-8 Chromatin/Epigenetic DNA Methyltransferase SGI-110 sodium S-110 sodium inhibitor inhibit

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