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GPP78

Catalog No. T15412   CAS 1202580-59-3
Synonyms: CAY10618

GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells (IC50: 3.8 nM by inducing autophagy). GPP78 has anti-cancer and anti-inflammatory effects.

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GPP78 Chemical Structure
GPP78, CAS 1202580-59-3
Pack Size Availability Price/USD Quantity
25 mg 6-8 weeks $ 1,520.00
50 mg 6-8 weeks $ 1,980.00
100 mg 6-8 weeks $ 2,500.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells (IC50: 3.8 nM by inducing autophagy). GPP78 has anti-cancer and anti-inflammatory effects.
In vitro GPP78 appears truly cytotoxic in melanoma cell lines, while in the others it is mainly cytostatic. GPP78 inhibits the growth of most cell lines tested, with nanomolar potency (GI50) in cell lines derived from leukemia, lung, CNS, colon, melanoma, ovarian, renal, and prostate cancers. GPP78 (10 nM; 24-40 hours; SH-SY5Y cells) treatment with cells, punctate staining of LC3-II, and the formation of autophagolysosomes are observable. LC3-II is membrane-bound and is present in autophagosomes [1].
In vivo GPP78 (i.p.; daily; 10 mg/kg; 1 hour or 6 hours after SCI; for 19 days; male adult CD1 mice) treatment decreases the severity of spinal cord trauma in SCI mice [2].
Synonyms CAY10618
Molecular Weight 439.55
Formula C27H29N5O
CAS No. 1202580-59-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Colombano G, et al. A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J Med Chem. 2010 Jan 28;53(2):616-23. 2. Esposito E, et al. The NAMPT inhibitor FK866 reverts the damage in spinal cord injury. J Neuroinflammation. 2012 Apr 10;9:66.

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Keywords

GPP78 1202580-59-3 Autophagy CAY10618 GPP 78 CAY-10618 GPP-78 CAY 10618 inhibitor inhibit

 

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