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Catalog No. T8525   CAS 133550-22-8
Synonyms: AG473

EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.

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EGFR-IN-16 Chemical Structure
EGFR-IN-16, CAS 133550-22-8
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5 mg 6-8 weeks $ 122.00
10 mg 6-8 weeks $ 195.00
25 mg 6-8 weeks $ 370.00
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Biological Description
Chemical Properties
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Description EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.
In vivo Expressed the Ag473 lipoprotein from Neisseria meningitides, flagellin FlaB from Vibrio vulnificus and heat shock protein 70 from Mycobacterium tuberculosis (mHsp70) in Escherichia coli as single proteins and fusion proteins with VP2 protein of infectious bursal disease virus (IBDV).?Both cellular and humoral adjuvanticities of the three TLR ligands were compared by immunization of mice in two different ways.?Among the three co-administered TLR ligands, recombinant Ag473 lipoprotein exhibited the highest cellular and humoral adjuvanticities, including promotion of IL-4, IL-12, IFN-γ and IBDV VP2-specific antibody production.?Among the three genetically fused TLR ligands, fusion with Ag473 D1 domain exhibited the highest cellular and humoral adjuvanticities.
Synonyms AG473
Molecular Weight 265.26
Formula C16H11NO3
CAS No. 133550-22-8


Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Lu H , Zhang X , Wang Y , et al. Superior adjuvanticity of the genetically fused D1 domain of Neisseria meningitides Ag473 lipoprotein among three Toll-like receptor ligands[J]. Bioence Reports, 2020, 40(4).

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EGFR-IN-16 133550-22-8 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors FGFR EGFR Epidermal growth factor receptor inhibit Inhibitor AG-473 ErbB-1 AG 473 HER1 EGFRIN16 AG473 EGFR IN 16 inhibitor