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EGFR-IN-16

Catalog No. T8525 CAS 133550-22-8

Synonyms: AG473

AG473 is an inhibitor of EGFR in human A431 cells.

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EGFR-IN-16, CAS 133550-22-8

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

AG473 is an inhibitor of EGFR in human A431 cells.

In vivo

Expressed the Ag473 lipoprotein from Neisseria meningitides, flagellin FlaB from Vibrio vulnificus and heat shock protein 70 from Mycobacterium tuberculosis (mHsp70) in Escherichia coli as single proteins and fusion proteins with VP2 protein of infectious bursal disease virus (IBDV).?Both cellular and humoral adjuvanticities of the three TLR ligands were compared by immunization of mice in two different ways.?Among the three co-administered TLR ligands, recombinant Ag473 lipoprotein exhibited the highest cellular and humoral adjuvanticities, including promotion of IL-4, IL-12, IFN-γ and IBDV VP2-specific antibody production.?Among the three genetically fused TLR ligands, fusion with Ag473 D1 domain exhibited the highest cellular and humoral adjuvanticities.

Synonyms	AG473
Molecular Weight	265.26
Formula	C16H11NO3?
CAS No.	133550-22-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Lu H , Zhang X , Wang Y , et al. Superior adjuvanticity of the genetically fused D1 domain of Neisseria meningitides Ag473 lipoprotein among three Toll-like receptor ligands[J]. Bioence Reports, 2020, 40(4).

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

EGFR-IN-16 133550-22-8 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR FGFR Epidermal growth factor receptor inhibit Inhibitor ErbB-1 AG473 HER1 EGFRIN16 EGFR IN 16 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.