Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | Inquiry | $ 747.00 |
Description | Daun02 is the topoisomerase inhibitor Daunorubicin prodrug. |
In vitro | Daun02 is converted by β-galactosidase to Daunorubicin, which has been shown to reduce Ca2+-dependent action potentials in neuroblastoma cells [1]. Daun02 is a good substrate for β-galactosidase (β-gal) and it also is a topoisomerase inhibitor [2]. The concentration of Daun02 producing 50% (EC50) decrease in cell viability is 0.5 μM, 1.5 μM, and 3.5 μM for T47-D, Panc02, and MCF-7, respectively [3]. |
In vivo | Daun02 is a good substrate for β-gal (Km and Vmax: 0.37 mM; protein: 8.6 μmol/min/mg). Daun02 is 79% bound to plasma protein compares to 94% for Daunomycin, at a concentration of 10 μM [3]. |
Molecular Weight | 884.79 |
Formula | C41H44N2O20 |
CAS No. | 290304-24-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (113.02 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Daun02 290304-24-4 DNA Damage/DNA Repair Topoisomerase Daun-02 inhibitor inhibit