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DNMDP

Catalog No. T15147 CAS 328104-79-6

DNMDP is a phosphodiesterase 3A inhibitor with clear cell-selective cytotoxicity. DNMDP binding to PDE3A promotes interaction between PDE3A and Schlafen 12.

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DNMDP, CAS 328104-79-6

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Biological Description

Chemical Properties

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Description	DNMDP is a phosphodiesterase 3A inhibitor with clear cell-selective cytotoxicity. DNMDP binding to PDE3A promotes interaction between PDE3A and Schlafen 12.
In vitro	DNMDP (0-1000 μM; 48 hours) displays clear cell-selective cytotoxicity. HeLa cells undergo apoptosis upon DNMDP treatment, indicates by caspase activity detected by a caspase-sensitive luciferase assay and by PARP cleavage. DNMDP (100 nM) specifically inhibits both PDE3A and PDE3B, but it weakly inhibits PDE10. It also had little or no detectable effect on other phosphodiesterases.

Molecular Weight	304.34
Formula	C15H20N4O3
CAS No.	328104-79-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. de Waal L, et al. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nat Chem Biol. 2016 Feb;12(2):102-8.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

DNMDP 328104-79-6 Others inhibitor inhibit

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