Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 6-8 weeks | $ 198.00 | |
25 mg | 6-8 weeks | $ 1,370.00 | |
50 mg | 6-8 weeks | $ 1,790.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM). |
Targets&IC50 | DNMT1:0.91 μM (kd), DNMT1:1.7 μM |
In vitro | DC_517 (0, 0.75, 1.5, and 3 μM) also dose-dependently induces apoptotic cell death in HCT116 cells. DC_517 (1.25, 2.5, 5, and 10 μM) effectively inhibits Capan-1 (human pancreatic adenocarcinoma cells) and the proliferation of HCT116 (human colon cancer) after treatment for 24, 48, and 72 h. |
Molecular Weight | 505.65 |
Formula | C33H35N3O2 |
CAS No. | 500017-70-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (98.88 mM)
You can also refer to dose conversion for different animals. More
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DC_517 500017-70-9 Chromatin/Epigenetic DNA Methyltransferase inhibitor inhibit