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CBP/p300-IN-2

Catalog No. T10702 CAS 2158265-96-2

Synonyms: CBP/EP300-IN-2

CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc) extracted from patent WO2017205538A1 (example 25).

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CBP/p300-IN-2, CAS 2158265-96-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc) extracted from patent WO2017205538A1 (example 25).
Targets&IC50	CBP/HTRF:1.07 nM , MYC:5.96 nM

Synonyms	CBP/EP300-IN-2
Molecular Weight	521.56
Formula	C27H29F2N7O2
CAS No.	2158265-96-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Patrick Cyr, et al. Pyrazolopyridine derivatives for the treatment of cancer

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Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

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Step Two: Enter the in vivo formulation

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CBP/p300-IN-2 2158265-96-2 表观遗传细胞周期 Epigenetic Reader Domain c-Myc CBP/p300 IN 2 CBP/EP300-IN-2 CBP/p300IN2 CBP/p-300-IN-2 Inhibitor inhibitor inhibit

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