Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BOS-318 is a Furin inhibitor with slowly dissociating, highly selective, and cell-pemeable characteristcs.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 159.00 | |
25 mg | In stock | $ 322.00 | |
50 mg | In stock | $ 513.00 | |
100 mg | In stock | $ 747.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 123.00 |
Description | BOS-318 is a Furin inhibitor with slowly dissociating, highly selective, and cell-pemeable characteristcs. |
In vitro | BOS-318 (0.001-1 μM) provides cytoprotection against toxicity in CuFi-1 cells induced by P aeruginosa exotoxin A (PEA). BOS-318 (U2OS cells) to be approximately 13 times more potent against furin than PCSK5 (IC50 = 25.3 nM), 24 times more potent that PCSK7 (IC50 = 45.8 nM), and 110 times more potent than PCSK6 (IC50 = 209.4 nM). BOS-318 (0.3 μM, 2h or 48 h)reduces ENaC-mediated Na+ absorption in CF HBECs and protects aganist NE- and CF sputum-sol-mediated activation of ENaC. [1] |
Molecular Weight | 571.5 |
Formula | C28H32Cl2N6O3 |
CAS No. | 2387633-15-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12.5 mg/mL (21.87 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BOS-318 2387633-15-8 Others Furin Inhibitor ENaC neutrophil elastase inhibit BOS318 BOS 318 inhibitor