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BMT-090605

Catalog No. T14691 CAS 1551403-51-0

BMT-090605 is a potent, selective AAK1 inhibitor, with an IC50 of 0.6 nM. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 45 and 60 nM, respectively[1]. BMT-090605 shows antinociceptive activity.

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BMT-090605, CAS 1551403-51-0

Pack Size	Availability	Price/USD
5 mg	8-10 weeks	$ 1,370.00 $ 1,096.00
50 mg	8-10 weeks	$ 2,780.00 $ 2,224.00
100 mg	8-10 weeks	$ 3,700.00 $ 2,960.00

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Purity: 98%

Biological Description

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Description	BMT-090605 is a potent, selective AAK1 inhibitor, with an IC50 of 0.6 nM. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 45 and 60 nM, respectively[1]. BMT-090605 shows antinociceptive activity.
In vitro	BMT-090605 shows a cellular IC50 of 0.63 ±0.39 nM for AAK1[1].
In vivo	BMT-090605 (0.3-3 μg/rat; intrathecally at lumbar level L5/L6) causes antinociception by inhibiting AAK1 in the spinal cord[1]. Exposure measurements from this study indicated that brain and plasma levels of BMT-090605 were <4 nM, whereas measurable levels (90–317 nM) were observed in lumbar spinal cord[1]. The high dose of BMT-090605 (3 μg/rat) showed efficacy comparable to intrathecal clonidine (3 μg/rat).

Molecular Weight	364.44
Formula	C21H24N4O2
CAS No.	1551403-51-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMT-090605 1551403-51-0 Others BMT090605 BMT 090605 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.