Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 2,720.00 | |
50 mg | 10-14 weeks | $ 3,580.00 | |
100 mg | 10-14 weeks | $ 4,900.00 |
Description | BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12). |
Targets&IC50 | murine MMP12:0.67 nM , human MMP12:0.085 nM , rat MMP12:1.1 nM |
In vitro | BAY-7598 inhibits human MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP13, MMP14, and MMP16 (IC50s: 44, 360, 600, 15, 460, 12, 67, 250, and 940 nM). BAY-7598 inhibits murine MMP2, MMP3, MMP7, MMP8, and MMP9 (IC50s: 45, 270, 130, 54, and 210 nM). BAY-7598 inhibits rat MMP2, MMP8, and MMP9 (IC50s: 45, 67, and 1000 nM). |
In vivo | BAY-7598 has moderate terminal elimination half-life (t1/2=4.1 h and 4.6 h for mouse (5.0 mg/kg, p.o.), mouse (0.3 mg/kg, iv), respectively). |
Molecular Weight | 505.56 |
Formula | C28H31N3O6 |
CAS No. | 1816257-74-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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BAY-7598 1816257-74-5 Others BAY7598 BAY 7598 inhibitor inhibit