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Apovincamine

Catalog No. T21047 CAS 4880-92-6

Synonyms: cis-Apovincamine

Apovincamine is a vinca alkaloid and a chemical precursor of Vinpocetine, which is a derivative of Vincamine with vasodilating activity.

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Apovincamine, CAS 4880-92-6

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Apovincamine is a vinca alkaloid and a chemical precursor of Vinpocetine, which is a derivative of Vincamine with vasodilating activity.

Synonyms	cis-Apovincamine
Molecular Weight	336.44
Formula	C21H24N2O2
CAS No.	4880-92-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Solovyeva EY, Karneev AN, Chekanov AV, Baranova OA, Choi IV. [Complex application 2-ethyl-6-methyl-3-hydroxypyridine-succinate and vinpocetine in cerebrovascular disorder.]. Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(5):103-108. doi: 10.17116/jnevro201711751103-108. Review. Russian. PubMed PMID: 28638040. 2. Feher G, Koltai K, Kesmarky G, Horvath B, Toth K, Komoly S, Szapary L. Effect of parenteral or oral vinpocetine on the hemorheological parameters of patients with chronic cerebrovascular diseases. Phytomedicine. 2009 Mar;16(2-3):111-7. doi: 10.1016/j.phymed.2008.10.014. Epub 2009 Jan 8. PubMed PMID: 19135345. 3. Szatmari SZ, Whitehouse PJ. Vinpocetine for cognitive impairment and dementia. Cochrane Database Syst Rev. 2003;(1):CD003119. Review. PubMed PMID: 12535455. 4. Jucker M, Bättig K, Meier-Ruge W. Effects of aging and vincamine derivatives on pericapillary microenvironment: stereological characterization of the cerebral capillary network. Neurobiol Aging. 1990 Jan-Feb;11(1):39-46. Erratum in: Neurobiol Aging 1990 Nov-Dec;11(6):675. PubMed PMID: 2325815.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Apovincamine 4880-92-6 cis-Apovincamine inhibitor inhibit

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