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Aplaviroc hydrochloride

Catalog No. T26642 CAS 461023-63-2

Synonyms: AK602, AK 602, GW873140A, GW-873140, GW873140, AK-602, Aplaviroc HCl

Aplaviroc is a human cellular CC chemokine receptor 5 (CCR5) entry inhibitor. Aplaviroc binds specifically to CCR5 and demonstrates potent anti-human immunodeficiency virus activity in vitro in the subnanomolar range. In vitro studies show that aplaviroc selectively inhibits the binding of a particular monoclonal antibody, 45531, to CCR5.

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Aplaviroc hydrochloride Chemical Structure

Aplaviroc hydrochloride, CAS 461023-63-2

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 1,140.00
50 mg	10-14 weeks	$ 1,490.00
100 mg	10-14 weeks	$ 2,360.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Aplaviroc is a human cellular CC chemokine receptor 5 (CCR5) entry inhibitor. Aplaviroc binds specifically to CCR5 and demonstrates potent anti-human immunodeficiency virus activity in vitro in the subnanomolar range. In vitro studies show that aplaviroc selectively inhibits the binding of a particular monoclonal antibody, 45531, to CCR5.
Targets&IC50	HIV-1 (MOKW):0.2 nM (IC50), HIV-1 (JRFL):0.1 nM (IC50), HIV-1 (Ba-L):0.4 nM (IC50)

Synonyms	AK602, AK 602, GW873140A, GW-873140, GW873140, AK-602, Aplaviroc HCl
Molecular Weight	614.17
Formula	C33H44ClN3O6
CAS No.	461023-63-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Latinovic O, Heredia A, Gallo RC, Reitz M, Le N, Redfield RR. Rapamycin enhances aplaviroc anti-HIV activity: implications for the clinical development of novel CCR5 antagonists. Antiviral Res. 2009 Jul;83(1):86-9. doi: 10.1016/j.antiviral.2009.02.199. Epub 2009 Mar 9. PubMed PMID: 19501260. 2. Yeni P, Lamarca A, Berger D, Cimoch P, Lazzarin A, Salvato P, Smaill FM, Teofilo E, Madison SJ, Nichols WG, Adkison KK, Bonny T, Millard J, McCarty D; EPIC (CCR100136) study team. Antiviral activity and safety of aplaviroc, a CCR5 antagonist, in combination with lopinavir/ritonavir in HIV-infected, therapy-naïve patients: results of the EPIC study (CCR100136). HIV Med. 2009 Feb;10(2):116-24. doi: 10.1111/j.1468-1293.2008.00660.x. PubMed PMID: 19200175. 3. Nolan KM, Del Prete GQ, Jordan AP, Haggarty B, Romano J, Leslie GJ, Hoxie JA. Characterization of a human immunodeficiency virus type 1 V3 deletion mutation that confers resistance to CCR5 inhibitors and the ability to use aplaviroc-bound receptor. J Virol. 2009 Apr;83(8):3798-809. doi: 10.1128/JVI.01751-08. Epub 2009 Feb 4. PubMed PMID: 19193800; PubMed Central PMCID: PMC2663279. 4. Kitrinos KM, Amrine-Madsen H, Irlbeck DM, Word JM, Demarest JF; CCR100136 Study Team. Virologic failure in therapy-naive subjects on aplaviroc plus lopinavir-ritonavir: detection of aplaviroc resistance requires clonal analysis of envelope. Antimicrob Agents Chemother. 2009 Mar;53(3):1124-31. doi: 10.1128/AAC.01057-08. Epub 2008 Dec 15. PubMed PMID: 19075068; PubMed Central PMCID: PMC2650553.

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Keywords

Aplaviroc hydrochloride 461023-63-2 AK602 Aplaviroc Hydrochloride AK 602 GW873140A GW-873140 GW873140 GW 873140 AK-602 Aplaviroc HCl inhibitor inhibit

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