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Amorolfine HCL

Catalog No. T8812 CAS 106614-68-0

Amorolfine HCL is an <a href="/target/Antifungal" style="display: inline; color: #c13a36">Antifungal</a> reagent. It exerts the <a href="/target/Antifungal" style="display: inline; color: #c13a36">Antifungal</a> activity by selectively interrupting two steps in the pathway of ergosterol synthesis and eventually disrupting the function and structure of fungal cell membrane. Amorolfine, a morpholine <a href="/target/Antifungal" style="display: inline; color: #c13a36">Antifungal</a> drug, can inhibit D14 <a href="/target/Reductase" style="display: inline; color: #c13a36">Reductase</a> and D7-D8 isomerase. These enzymes can deplete ergosterol and cause ignosterol to accumulate in the fungal cytoplasmic cell membranes.

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Amorolfine HCL, CAS 106614-68-0

Pack Size	Availability	Price/USD	Quantity
5 mg	Inquiry	$ 50.00
1 mL * 10 mM (in DMSO)	Inquiry	$ 50.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Amorolfine HCL is an antifungal reagent. It exerts the antifungal activity by selectively interrupting two steps in the pathway of ergosterol synthesis and eventually disrupting the function and structure of fungal cell membrane. Amorolfine, a morpholine antifungal drug, can inhibit D14 reductase and D7-D8 isomerase. These enzymes can deplete ergosterol and cause ignosterol to accumulate in the fungal cytoplasmic cell membranes.

Molecular Weight	353.98
Formula	C21H36ClNO
CAS No.	106614-68-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 3.33 mg/mL (9.41 mM), Need ultrasonic

DMSO: 12.5 mg/mL (35.31 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Espinel-Ingroff A, et al. Antimicrob Agents ChemOthers. 1984 Jul; 26(1):5-9. 2. Polak, A., Preclinical data and mode of action of amorolfine. Dermatology, 1992. 184 Suppl 1: p. 3-7.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Amorolfine HCL 106614-68-0 Microbiology/Virology Antibiotic Inhibitor inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.