Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ATB107 is a potent and novel inhibitor of indole-3-glycerol phosphate synthase (IGPS, KD: 3 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | ATB107 is a potent and novel inhibitor of indole-3-glycerol phosphate synthase (IGPS, KD: 3 μM). |
Targets&IC50 | IGPS:(kd)3 μM |
In vitro | ATB107 exhibits potent antibacterial activity against M. tuberculosis H37Ra and H37Rv strains with a minimum inhibitory concentration (MIC) of 0.1 μg/mL. Additionally, it effectively inhibits 100% of 50 fully susceptible clinical isolates at a concentration of 1 μg/mL, and 82% of these isolates at a concentration of 0.1 μg/mL. Among multidrug-resistant TB (MDR-TB) isolates, 83.8% are susceptible to ATB107 at 1 μg/mL, with a lower susceptibility rate of 31.3% observed at 0.1 μg/mL. Furthermore, the efficacy of ATB107 is concentration-dependent, correlating directly with its binding ability. Specifically, at a concentration of 200 μg/mL, ATB107 impedes cell proliferation, resulting in a survival rate of approximately 60%. Conversely, a lower concentration of 50 μg/mL ensures a cell survival rate exceeding 80%, highlighting its potency and concentration-dependent effects. |
Molecular Weight | 392.5 |
Formula | C21H28N8 |
CAS No. | 455325-51-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ATB107 455325-51-6 Others ATB 107 ATB-107 inhibitor inhibit