keep away from direct sunlight,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ADRA1D receptor antagonist 1 HCl is an orally active, potent and selective α1D adrenergic receptor antagonist (Ki: 1.6 nM) with potential antiproliferative activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | ADRA1D receptor antagonist 1 HCl is an orally active, potent and selective α1D adrenergic receptor antagonist (Ki: 1.6 nM) with potential antiproliferative activity. |
Targets&IC50 | α1D-adrenoceptor:1.6 nM (Ki) |
In vitro | ADRA1D receptor antagonist 1 exhibits low hERG inhibition and higher selectivity for α1D-AR over α1A- and α1B-ARs, without affecting α1A- and α1B-ARs[1]. |
In vivo | In the rat model of bladder outlet obstruction (BOO), ADRA1D receptor antagonist 1 (4.4 µg/kg; intravenous injection) dose-dependently decreased the occurrence of non-voiding bladder contractions during the urinary storage phase[1]. |
Animal Research | Animal Model: Rat with bladder outlet obstruction (BOO). Dosage: 4.4 μg/kg. Administration: Intravenous injection |
Synonyms | ADRA1D receptor antagonist 1 HCl(1191908-24-3 free base) |
Molecular Weight | 337.2 |
Formula | C15H14Cl2N4O |
CAS No. | 1191908-14-1 |
keep away from direct sunlight,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (237.25 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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ADRA1D receptor antagonist 1 HCl 1191908-14-1 GPCR/G Protein Neuroscience Adrenergic Receptor ADRA1D receptor antagonist 1 ADRA-1D receptor antagonist 1 ADRA1D receptor antagonist 1 HCl(1191908-24-3 free base) inhibitor inhibit